The platform that responds to the challenges of PFAS, a family of chemical substances essential to our economy but known for their toxicity and their persistence in the environment

What is Preludéa ? 

Preludéa® is a platform that responds to the challenges of per- and polyfluoroalkyl substances (PFAS), a family of chemicals essential to our economy but known for their toxicity and persistence in the environment.  

To face PFAS drawbacks, Harmonic Pharma introduces the Preludéa® platform, which incorporates a new alternative method for classifying, comparing, ranking and substituting PFAS.

How it works ?

The innovative solution is based on OECD compliant toxicity predictions coupled with artificial intelligence, target analysis and spherical harmonics, 3D digital descriptors from which the company takes its name.

Who is concerned ?

Preludéa® is offered to professionals: engineers, researchers, senior technicians, executives, product managers, service managers, toxicologists and chemists from the various departments affected, such as those of Innovation, QSE, CSR, management, quality, Research and Development willing to acquire new skills, to discover and to find out insights for remediation stategy.


Per- and polyfluoroalkyl substances (PFAS) are a large family of several thousand synthetic chemicals that are commonly used throughout society and found in the environment. PFAS, also known as “Forever Chemicals”, are compounds containing a very stable “Carbon-Fluorine” bond. PFAS do not degrade after use or discharge into the environment because of this bond, which is one of the strongest in organic chemistry.


The 2001 Stockholm Convention is an international agreement that regulates several compounds of the PFAS family :

2009 : The production and use of PFOS have been restricted.

2020 : PFOA has been banned for import, export and production


November 23, 2022 : PFHxS was added to the European regulation on persistent organic pollutants (POP – annex IV concerning the treatment of waste)
January 13, 2023 : The national authorities of Denmark, Germany, the Netherlands, Norway and Sweden have submitted a proposal to ECHA to restrict per- and polyfluoroalkyl substances (PFASs) under REACH, the European Union’s (EU) chemicals regulation.


January 17, 2023 : The Ministry of Ecological Transition and Territorial Cohesion has published a ministerial action plan on PFAS, with the aim of strengthening the protection of populations and the environment against the risks associated with those compounds.

June 20, 2023 : A ministerial order was issued, relating to the analysis of PFAS in aqueous discharges from ICPEs (Installations classified for the protection of environment) subject to the authorization system.

July 18, 2023 : Application note providing clarifications and recommendations for the order of June 20.

A regulation that will strengthen

2026 : The regulatory framework will evolve by 2026. European directive 2020/2184 concerning the quality of water for human consumption has been completely revised to monitor the presence of PFAS in water analyses.

An innovative platform that integrates services, software and dedicated training to help organizations in the decision making process on PFAS issues.





A new alternative method based on OECD-compliant toxicity predictions

This method gives the opportunity to discriminate the most problematic molecules and prioritize families of molecules that need to be monitored more specifically because of the lack of experimental data.

In addition, Preludéa® allows the exploration and evaluation of the possibility of substituting problematic PFAS compounds.


Preludéa® integrates the Safety By Design® software

The software allows the classification, comparison and overall evaluation of PFAS compounds on a large scale even in the absence of experimental data.

Example of toxicity prediction for Perfluorooctanesulfonic acid (PFOS) – captured from the software.

Target analysis

Example of automated report.


Preludéa® includes dedicated traning

At the end of the two days training session, learners will have learned:

  • Knowledge on the fundamentals of PFAS;
  • The ability to master a specialized solution (Safety by Design®);
  • The ability to assess PFAS issues and try to implement corrective measures.

Contact us for more information


    Informations pour le module de formation

      23-24 octobre27-28 novembre13-14 décembre


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